与宿主相关的有益肠道微生物群增强了诱导免疫力,并限制了熊蜂的免疫部署成本
Austin C Calhoun1,2, Teni Shosanya1,3, Brenna K Long1
1School of Biological Sciences, Illinois State University, Normal, Illinois, USA.
The Journal of animal ecology
|November 10, 2025
概括
熊蜂的肠道微生物群增强了免疫防御,并大大降低了与激活免疫反应相关的生存成本,突出显示了微生物群在免疫中的关键作用.
科学领域:
- 生态免疫学 生态免疫学
- 微生物群与宿主相互作用
- 昆虫的免疫力 昆虫的免疫力
背景情况:
- 免疫防御的激活对宿主产生生态和进化成本.
- 与宿主相关的微生物群影响宿主特征,包括免疫力.
- 微生物群在减轻免疫激活成本中的作用在很大程度上是未知的.
研究的目的:
- 测试大黄蜂肠道微生物群是否能减轻诱导性免疫反应的成本.
- 调查微生物群对大黄蜂免疫功能和生存成本的影响.
主要方法:
- 没有细菌的成年大熊蜂工人通过便移植实验殖民本地肠道微生物群或保持微生物群剥夺.
- 评估了诱导免疫的功能性措施.
- 评估了非致病性免疫激活对生存的成本.
主要成果:
- 微生物群补充剂显著增强了功能性抗菌免疫力.
- 免疫激活带来了生存成本,在缺乏微生物群的蜜蜂中,相比于得到补充的蜜蜂,这些生存成本要大得多.
结论:
- 熊蜂肠道微生物群减轻了与免疫防御部署相关的成本.
- 与宿主相关的微生物群在启动诱导免疫反应方面发挥着关键作用.
- 这项研究加深了对生态免疫学中的微生物群-免疫相互作用的理解.
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