工程益生菌重塑瘤 免疫微环境
Yuejun Jiang1,2, Yicheng Ye2, Hong Wang2
1Department of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
ACS nano
|November 10, 2025
概括
与纳米颗粒混合的工程益生菌提供了一种新的癌症治疗方法. 这种方法增强了瘤向性,并利用超声波产生抗癌的活性氧物种,促进免疫治疗.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症免疫疗法癌症免疫疗法
背景情况:
- 活体治疗,比如细菌,对癌症治疗有希望,但有效性有限.
- 用合成材料混合细菌可以增强治疗功能和瘤向.
- 目前的细菌疗法在临床转化方面面临挑战,因为治疗潜力有限.
研究的目的:
- 开发一种先进的基于微生物的免疫疗法,以加强瘤向和治疗.
- 为了混合αPD1抗体工程 *Lactobacillus rhamnosus* GG (LGG) 与BaTiO3纳米粒子 (BTO NP) 进行协同抗癌作用.
- 调查超声触发BTONP的潜力,以产生活性氧物种和瘤微环境调制.
主要方法:
- 工程 LGG 细菌与瘤向的 αPD1 抗体.
- 混合LGG与sonopiezocatalyticBTO纳米颗粒的混合.
- 使用超声波照射激活BTONP用于产生活性氧物种 (ROS).
- 利用LGG的缺氧亲和力,对瘤区域进行向传递.
- 评估诱导免疫细胞死亡 (ICD) 和抗瘤免疫激活.
主要成果:
- 工程混合系统证明了增强的瘤特异性积累.
- 对BTONP的超声波照射有效地产生ROS,诱导瘤细胞中的ICD.
- 在sonopiezocatalysis期间的氧气生产减轻了瘤缺氧.
- 治疗显著增强了抗瘤免疫反应,增强了免疫检查点阻塞 (ICB) 疗法的有效性.
- 与非混合组件相比,混合系统显示了改善的治疗结果.
结论:
- 与BTO NP混合的工程益生菌代表了针对癌症免疫治疗的有希望的战略.
- 开发的系统提供了超声波可控制的催化疗法,具有双重作用:ROS生成和免疫系统激活.
- 这种方法克服了原始微生物的局限性,并提高了现有的癌症治疗方法 (如ICB疗法) 的疗效.
更多相关视频
11:003D Flipwell Engineering for Developing Asynchronous Systems for Toxicologic and Immunomodulatory Therapies in Bacterial, Gut, and Immune Cells
Published on: October 17, 2025
306
06:07Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
7.1K
相关概念视频
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Microorganisms in Medicine and Therapeutics
922
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
922
