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从愿景到现实:植物安全联盟的五年
Constance A Mitchell1, Amy L Roe2, Scott Auerbach3
1Health and Environment Sciences Institute, Washington, District of Columbia, USA.
Pharmaceutical biology
|November 10, 2025
概括
植物安全测试正在不断发展,使用新的方法来评估复杂的植物,真菌和藻类产品. 植物安全联盟 (BSC) 正在开发先进的工具,以确保这些产品对消费者是安全的.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 来自植物,真菌和藻类的植物产品在全球范围内被广泛消费.
- 它们复杂和可变的植物化学特征对安全评估构成重大挑战.
- 传统的毒理学方法资源密集,可能无法充分反映植物变异性.
研究的目的:
- 总结植物安全联盟 (BSC) 在推进适合植物性毒性测试策略方面取得的进展.
- 突出BSC工作组在评估新方法方法 (NAM) 的活动.
主要方法:
- 在植物危害评估中,BSC工作组评估了体外测试,模型和未受保护的整个生物体 (例如C. elegans).
- 使用具有已知的毒性概况的植物性物质的案例研究被用于评估测试性能.
- 该研究确定了植物在这些测试系统中与单一化学品相比,植物是否表现出不同的行为.
主要成果:
- 评估涵盖了毒理终点,包括肝毒性,基因毒性,生殖毒性,神经毒性,心脏毒性和皮肤毒性.
- 早期的发现表明,需要确定适用于植物学测试的一般选工具,并考虑具体问题.
- 该研究确定了适合用于植物安全评估的选工具.
结论:
- 未来的工作将通过测试增强和ADME数据和in silico建模的整合来完善和扩展工具包.
- BSC的合作框架旨在现代化植物安全评估并解决监管需求.
- 该倡议通过确保植物产品的安全性,同时满足全球需求,支持公共卫生.
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