奥西蒙圣地多的神经保护潜力:机制和治疗影响
Nikhat Parween1, Saurabh Pandey1, Birendra Prasad2
11Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi-110062.
Iranian biomedical journal
|November 10, 2025
概括
圣 (O. sanctum) 的多显示出神经保护神经退行性疾病的前景. 它们的抗氧化和抗炎性质可能为传统治疗提供一种天然的替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 自然产品化学 自然产品化学
背景情况:
- 神经退行性疾病 (NDD) 由于神经元的逐渐丧失,对全球健康构成重大负担.
- 自然化合物,特别是植物性多,正因其神经保护能力而受到越来越多的研究.
- 圣 (Ocimum sanctum) 的多具有与神经保护相关的多种药理活性.
研究的目的:
- 审查Ocimum圣地多的神经保护潜力.
- 阐明它们在神经退行性疾病中的治疗作用背后的机制.
- 评估从临床前和临床研究中获得的关于其有效性和安全性的证据.
主要方法:
- 关于Ocimum sanctum多和神经保护的临床前和临床研究的文献综述.
- 对O. sanctum的化学成分的分析,重点是聚化合物.
- 检查体外和体内研究表明抗氧化,抗炎,抗丧和突触可塑性调节作用.
主要成果:
- O. sanctum的多,包括黄,酸和素,通过清除自由基和增强内源抗氧化防御,表现出强大的抗氧化活性.
- 这些化合物具有显著的抗炎性质,调节细胞因子的产生,减少神经炎症.
- 临床前的NDD模型显示出有希望的神经保护作用,早期的临床数据表明安全性和潜在的疗效.
结论:
- 在Ocimum sanctum中,聚醇表现出多方面的神经保护机制,包括抗氧化,抗炎和抗丧作用.
- 这些发现支持O. sanctum多的潜在发展,作为神经退行性疾病的治疗剂.
- 对这些机制的进一步研究可能会导致改善NDD的治疗方法和患者的治疗结果.
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