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Updated: Jan 11, 2026

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长期托西利祖马布治疗耐皮质固醇活性中度至重度甲状腺眼病患者
Florian Dalmas1,2, Clémence Foing3, Geneviève Darrason1
1Department of Ophthalmology, Hôpital Nord, Assistance Publique - Hôpitaux de Marseille (AP-HM), Marseille 13015, France.
European journal of endocrinology
|November 10, 2025
概括
托西利祖马布 (TCZ) 有效治疗耐皮质激素的甲状腺眼病 (TED),超过一半的患者在六个月内出现改善. 持续治疗可能会带来进一步的益处,MRI可以帮助管理.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 可能是严重的,并且可以抵抗标准的皮质类固醇治疗.
- 对抗皮质类固醇耐药TED治疗的长期疗效需要进一步研究.
研究的目的:
- 评估托西利祖马布 (TCZ) 在中度至重度,耐皮质固醇TED患者的长期疗效.
- 评估TCZ对临床活性评分 (CAS),proptosis,双眼视,眼内压力 (IOP) 和甲状腺刺激免疫球蛋白 (TSI) 的影响.
主要方法:
- 一项对26名耐皮质固醇TED患者进行的回顾性研究,这些患者接受了12个月的TCZ治疗.
- 主要终点:在TCZ启动后的六个月内CAS<3.
- 二级终点:在18个月的时间里,proptosis,双眼,IOP,TSI和MRI信号强度比率 (SIR) 的变化.
主要成果:
- 58%的患者在六个月内达到CAS<3 (P<.001).
- 在随访期间观察到CAS,proptosis,diplopia,IOP和TSI水平的显著降低.
- 磁力共振成像显示,半年后SIR和轨道肌肉厚度显著下降.
结论:
- 六个月的TCZ治疗控制了超过一半的患者中度至重度的皮质类固醇耐药TED.
- TCZ可以提供超过六个月的持续或额外福利.
- 磁共振成像 (MRI) 可能是管理TED的宝贵工具.
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