在第三阶段非小细胞肺癌中新辅助化学免疫疗法或化学辐射疗法:跨越鲁比康?
Juan Carlos Redondo-González1, Luis Posado-Domínguez1, Laura Corvo-Félix1
1Department of Medical Oncology, Salamanca University Hospital, Salamanca, Spain; Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Chinese clinical oncology
|November 10, 2025
概括
新辅助化疗免疫疗法 (CT-IO) 与标准化疗辐射疗法 (CT / RT) 相比,在第三阶段非小细胞肺癌 (NSCLC) 中显示出更好的结果. CT-IO正在成为大多数IIIA和IIIB期NSCLC患者的新标准.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 癌症研究 癌症研究
背景情况:
- 肺癌是全球癌症死亡的主要原因之一.
- 非小细胞肺癌 (NSCLC) 占病例的80-85%,其中很大一部分在第三阶段被诊断出来.
- 第三阶段NSCLC呈现异质特征,包括可切除和不可切除的疾病表现.
研究的目的:
- 审查目前关于治疗第三阶段NSCLC的证据.
- 为了比较新辅助化疗免疫疗法 (CT-IO) 与标准化疗放射疗法 (CT/RT),其次是巩固性免疫疗法.
- 评估第三阶段NSCLC的不断变化的治疗环境.
主要方法:
- 临床试验和研究的叙述性综述.
- 在主要数据库中进行的搜索:PubMed,Cochrane,Science Direct,EMBASE和clinicaltrials.gov.gov.
主要成果:
- 新辅助CT-IO在IIIA/IIIB期NSCLC中显示出优异的病理完整反应 (pCR),无事件生存 (EFS) 和整体生存 (OS).
- 同时CT/RT接着杜尔瓦卢马布是不可切除的第三阶段疾病 (PACIFIC试验) 的既定标准.
- 新出现的数据表明,CT-IO可能成为IIIA阶段和选择的IIIB/IIICNSCLC患者的新标准,尽管试验异质.
结论:
- 新辅助CT-IO提供了显著的转变,为第三阶段NSCLC提供了个性化和潜在的更有效的选择.
- 对于大多数IIIA和IIIB期NSCLC患者,CT-IO应该被强烈考虑.
- 同时的CT/RT对于特定的子集至关重要,如T4或不可切除的瘤.
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