骨肌团和炎症脂肪组织的微生理学接口,用于总结肥胖微环境中的肌肉功能障碍
Seunggyu Kim1,2,3, Tianxin Cao4, Zhengpeng Wan5
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
Advanced healthcare materials
|November 10, 2025
概括
肥胖引起的炎症会损害骨肌肉的功能. 一个新的微生理系统模拟了这种相互作用,揭示了炎症脂肪组织如何破坏肌肉收缩和新陈代谢.
科学领域:
- 生物医学工程 生物医学工程
- 细胞生物学 细胞生物学
- 生理学 生理学 生理学
背景情况:
- 肥胖导致全身炎症,通过脂肪组织信号负面影响骨肌肉功能.
- 现有的模型缺乏研究肥胖相关功能障碍中的脂肪肌肉交叉的生理相关性.
研究的目的:
- 开发一种基于人类细胞的微生理系统,以模拟与肥胖相关的骨肌肉功能障碍.
- 研究炎症脂肪组织对骨肌肉收缩性和新陈代谢的影响.
主要方法:
- 来自人类肌细胞的工程肌肉组织 (EMT) 形成了3D收缩性肌肉捆.
- 炎症脂肪巨共同培养 (IAMC) 再现了肥胖的炎症微环境.
- 使用EMT-IAMC共同培养来评估肌肉功能和分子变化.
主要成果:
- 共同培养显著降低了骨肌肉收缩性.
- 检测到高的亲炎性介质.
- 转录组分析显示了肌肉中的代谢重编程,包括胰岛素抵抗标志物.
结论:
- 炎症的脂肪组织有害地影响骨肌肉功能.
- 开发的平台对于研究脂肪肌相互作用和查与肥胖相关的肌肉功能障碍的治疗方法非常有价值.
相关概念视频
01:11Introduction to Connective Tissues
19.2K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
19.2K
01:02Hypodermis
7.8K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
7.8K