通过古代基因组推算推断家养山羊的人口历史
Jolijn A M Erven1,2, Alice Etourneau3, Marjan Mashkour4,5
1UCD School of Agriculture and Food Science, University College Dublin, Belfield, Ireland.
Genome biology and evolution
|November 10, 2025
概括
基因型归因改进了古代山羊基因组分析,揭示了化影响. 这种方法增强了低覆盖率的古代DNA数据,显示了早期山羊分散如何影响遗传多样性和近亲繁殖.
科学领域:
- 古代的基因组学 古代的基因组学
- 化研究 化研究
- 人口遗传学 人口遗传学
背景情况:
- 羊是早期的化动物,对研究化的遗传影响有价值.
- 古代样本中基因组覆盖率较低的分析局限于伪类基因型.
- 基因型归算可以提高低覆盖基因组的信息内容和准确性.
研究的目的:
- 评估基因型归算对改善古代山羊古遗传组分析的有用性.
- 调查早期山羊管理和分散的人口历史和遗传后果.
主要方法:
- 使用大型参考面板 (VarGoats) 计算下方样本的高覆盖率山羊古遗传组.
- 通过测量被归算和高覆盖基因型之间的一致性来评估归算准确性.
- 在指定的古遗传组中分析同卵性运行 (ROH) 和身份由血统 (IBD).
主要成果:
- 在对常见变异进行过后,在0.5×覆盖基因组中实现了高一致性 (>0.97).
- 在覆盖范围,基因型概率值和基因型恢复/准确性之间确定了权衡.
- 在新石器时代的山羊中,ROH随着距离扎格罗斯山脉的距离而增加,这表明分散效应.
- 随着时间的推移,内生繁殖水平下降,IBD模式反映了早期牧场动态.
结论:
- 基因型归因是利用低覆盖率的古老山羊基因组的一个有价值的工具.
- 早期山羊的分散显著影响了种群遗传学,随着时间的推移,近亲繁殖的减少.
- 该研究提供了关于早期动物管理对人口学的遗传后果的见解.
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