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Updated: Jan 11, 2026

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提高了对GSH敏感的mPEG-b-P(HPMA) -SGI1776对骨髓瘤的结合物的药理动力学和治疗效果

Xingchen Shi1, Rourou Wang2, Zhenghua Zhang3

  • 1Orthopedics Department of Lanzhou Second People's Hospital, Lanzhou, China.

Frontiers in pharmacology
|November 10, 2025
PubMed
概括

这项研究开发了SGI-1776的聚合原药,用于骨髓瘤治疗. 在临床前模型中,新型结合剂显示改善了药物输送,降低了毒性,并增强了抗癌效应.

关键词:
具有GSH响应性的在SGI-1776中使用.骨质肉瘤是骨质肉瘤的一种疾病.药物动力学 药物动力学聚合原药是一种多重原药.

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates08:47

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Drug Metabolism: Phase II Reactions

Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
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