手术关闭心室隔膜缺陷后的长期结果:纵向随访到第五个十年
Sahra Ünlütürk1, Robert M Kauling1,2, Judith A A E Cuypers1,2
1Department of Cardiology, Cardiovascular Institute, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands.
International journal of cardiology. Congenital heart disease
|November 10, 2025
概括
手术关闭腹腔隔膜缺陷 (VSD) 后的长期存活率很好,在49岁时的存活率为77%. 生活质量保持稳定,尽管无事件生存率为50%,由于心律失常和起器需求等并发症.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 成年人的先天性心脏病
背景情况:
- 腹腔隔膜缺陷 (VSD) 的手术关闭是一种常见的程序.
- 在VSD关闭后,关于生存,临床事件和生活质量 (QoL) 的长期结果对于患者管理至关重要.
研究的目的:
- 为了评估长期存活,临床结果和高达49岁的生命质量 (QoL),术后腹腔隔膜缺陷 (VSD) 关闭.
主要方法:
- 一个单中心的纵向队列研究跟踪了1968年至1980年间连续接受手术关闭VSD的患者.
- 患者每十年接受一次广泛的心脏和QoL评估.
主要成果:
- 49岁的生存率为77% (86%不包括早期死亡率). 无事件生存率为50%,常见并发症包括症状性心律失常 (10%),心脏起器植入 (8%) 和VSD相关干预 (3%).
- 晚期并发症包括左心房扩张 (58%) 和大动脉吐 (25%). 左心室喷射小部分保持稳定.
- 尽管一些人的运动能力有所降低,但自我感知的QoL是稳定的,与一般人群相比.
结论:
- 手术关闭VSD提供了良好的长期生存,但无事件的生存受到并发症的限制.
- 早期的术后心律失常是死亡率的预测因素.
- 生活质量通常很好,并在手术后的几十年内保持良好.
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