重编程瘤微环境以促进采用T细胞治疗
Maria Fernanda Meza Pacheco1,2, Lee-Hwa Tai1,2
1Departement of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Frontiers in immunology
|November 10, 2025
概括
下一代采用性T细胞疗法 (ACT) 需要克服免疫抑制性瘤微环境 (TME). 策略包括重新编程TME并将ACT与传统治疗相结合,以获得更好的固体瘤结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物工程是生物工程.
背景情况:
- 采用T细胞疗法 (ACT) 在血液癌症中表现有前途,但在固体瘤中面临挑战.
- 瘤微环境 (TME) 由于其复杂性和免疫抑制性质,是一个重要的障碍.
研究的目的:
- 审查新兴的增强ACT在固体瘤中的疗效策略.
- 为未来的ACT开发提出一个综合方法,重点关注T细胞-TME相互作用.
主要方法:
- 对TME重编程策略的综合文献综述.
- 分析新兴疗法及其临床转化潜力.
- 探索将传统疗法与ACT整合起来.
主要成果:
- 通过修改TME,几种策略可以提高ACT的疗效,包括血管重编程,髓状细胞再极化,瘤病毒,无菌炎症诱导和向细胞外基质.
- 一些新的方法正在进行临床试验.
- 传统疗法可以战略性地与ACT结合.
结论:
- 未来ACT在固体瘤中的成功取决于重编程TME以支持T细胞功能.
- 结合T细胞工程与TME调制的综合方法至关重要.
- 跨学科的合作对于推动ACT的发展至关重要.
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