益生菌和T细胞免疫之间的交叉关系
Yuanyuan Liu1, Xu Cao2, Hongwei Liu1
1Institute of Biology, Hebei Academy of Sciences, Shijiazhuang, Hebei, China.
Frontiers in immunology
|November 10, 2025
概括
益生菌显著影响T细胞反应,影响免疫平衡和疾病预防. 了解这种益生菌-T细胞轴为免疫调节提供了新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 益生菌补充剂是一种公认的健康维护策略.
- 益生菌在自身免疫性疾病,代谢障碍和癌症免疫疗法中显示出治疗潜力.
- 在各种疾病中,T细胞介导的免疫反应至关重要.
研究的目的:
- 为了阐明益生菌微生物和T细胞之间的交叉声.
- 探索益生菌如何调节T细胞分化,激活,增殖和功能.
- 通过T细胞轴揭示益生菌在免疫调节和疾病预防方面的潜力.
主要方法:
- 文献综述侧重于T细胞介导反应和疾病.
- 对益生菌和T细胞的实验和机制研究的分析.
- 检查CD4+和CD8+T细胞子集的益生菌调制.
主要成果:
- 益生菌与T细胞密切交互,影响它们的子集.
- 益生菌调节关键的T细胞功能,影响免疫反应.
- 益生菌-T细胞轴是免疫恒温的重要因素.
结论:
- 了解益生菌-T细胞相互作用对于免疫调节至关重要.
- 益生菌对新的治疗策略和预防措施具有前景.
- 准益生菌-T细胞轴可以促进免疫相关疾病的治疗.
相关概念视频
T Cell Activation and Clonal Selection
14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
Cell-mediated Immune Responses
83.4K
Overview
83.4K
T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Special Features of Adaptive Immunity
2.9K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.9K
Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
Cytotoxic T Cells-mediated Immune Response
6.4K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.4K


