在接受Rituximab治疗的原发性淋巴细胞疾病中,肺部感染的风险评估
1Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Frontiers in immunology
|November 10, 2025
概括
肺部感染发生在接受Rituximab (RTX) 治疗的原发性淋巴细胞疾病 (PGD) 患者中的15.85%. 较低的血清白蛋白 (sALB) 和更高的估计球过率 (eGFR),补充成分3 (C3) 和年龄与感染风险有关.
科学领域:
- 腎病學和免疫學 腎病學和免疫學
- 传染病流行病学 传染病流行病学
- 药物监督 药物监督 药物监督
背景情况:
- 利图西马布 (RTX) 是一种有效的治疗原发性淋巴细胞疾病 (PGDs).
- 然而,RTX可以增加感染的风险,需要对PGD患者的肺感染发病率和风险因素进行评估.
- 了解这些风险对于优化RTX治疗期间的患者管理和安全至关重要.
研究的目的:
- 确定接受RTX的PGD患者肺部感染的发病率.
- 为了确定与肺部感染的发展相关的临床风险因素,在RTX给药后的六个月内.
- 探索RTX治疗参数与感染风险之间的关系.
主要方法:
- 对246名接受RTX治疗的PGD患者的临床数据进行了回顾性分析.
- 数据收集包括患者人口统计,疾病特征,实验室值,RTX剂量和6个月内肺部感染的发生情况.
- 使用统计分析,包括后勤回归 (LASSO) 和考克斯比例危险模型,以确定风险和保护因素.
主要成果:
- 在RTX治疗6个月内肺部感染的发病率为15.85%.
- 感染的独立风险因素包括较高的年龄,较低的血清白蛋白 (sALB),较低的估计膜过率 (eGFR) 和较低的补体成分3 (C3).
- 潜在结核病也被确定为危险因素,而sALB则成为保护因素.
结论:
- 在接受RTX治疗的PGD患者中,肺部感染是一个重大问题,在6个月内发生的患者数量为15.85%.
- 血清白蛋白 (sALB) 起着保护因素的作用,而年龄,C3和eGFR是这些感染的独立风险因素.
- RTX剂量和同时服用的免疫抑制剂没有显著影响感染风险,这突显了监测特定临床参数的重要性.
相关概念视频
Nephrotic Syndrome I : Introduction
484
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
484
Pulmonary Tuberculosis I
816
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
816
Renal Corpuscle
6.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.9K
Factors Affecting Renal Clearance: Renal Impairment
407
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
407
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
178
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
178
Acute Kidney Injury IV: Diagnostic Studies and Prevention
254
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
254


