维生素D与心血管疾病:"好"",坏"和"未知"
Domenico Mario Giamundo1, Matteo Morello2,3, Paola Pastena4
1Department of Systems Medicine, University Tor Vergata, 00133 Rome, Italy.
Reviews in cardiovascular medicine
|November 10, 2025
概括
维生素D缺乏是常见的,并与心血管问题有关. 虽然研究表明有好处,但目前关于维生素D补充剂对心脏健康的证据仍然没有确定性,需要进一步调查.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D对和的平衡至关重要,缺乏是全球普遍存在的.
- 新出现的证据表明,维生素D的作用超出骨健康范围,影响心血管系统.
- 临床前数据表明,维生素D可能会影响血管度和心脏重塑.
研究的目的:
- 综合审查维生素D与心血管疾病之间的多方面的关系.
- 探索维生素D在心血管健康中的"好" (潜在益处),"坏" (风险) 和"未知"方面.
- 综合目前对维生素D在高血压,动脉样硬化和心力衰竭等疾病中的作用的理解.
主要方法:
- 临床前和干预研究的系统审查.
- 流行病学数据分析,将维生素D水平与心血管风险联系起来.
- 评估维生素D对心血管的影响背后的生物机制.
主要成果:
- 维生素D缺乏与高血压,动脉样硬化和心力衰竭的风险增加有关.
- 临床前研究表明,维生素D有潜在的心脏保护作用,包括抗纤维和抗重塑作用.
- 对预防或治疗心血管疾病的维生素D补充剂的临床试验证据是不一致和不确定的.
结论:
- 维生素D在心血管疾病中的确切作用和治疗潜力仍然不确定.
- 需要进一步进行精心设计的临床试验,以澄清维生素D补充剂对心血管健康的益处和风险.
- 了解"好"",坏"和"未知的"方面对于指导临床实践和未来研究至关重要.
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