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与葡萄糖和脂质代谢障碍有关的心血管损伤的分子机制和精确干预方面的进展
Li Wu1, Jiyao Xu2, Chenxia Wu1,3
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China.
葡萄糖和脂质代谢障碍 (GLMDs) 通过代谢炎症,脂毒性,代谢记忆和肠心轴问题驱动心血管损伤. 新兴的精确策略显示出治疗诸如动脉样硬化心血管疾病和心力衰竭等相关疾病的前景.
科学领域:
- 心血管研究研究心血管研究
- 代谢障碍 代谢障碍 代谢障碍
- 分子生物学分子生物学
背景情况:
- 葡萄糖和脂质代谢障碍 (GLMDs) 越来越多地与心血管并发症有关.
- 动脉样性心血管疾病 (ASCVD),糖尿病心肌病 (DbCM),心力衰竭 (HF) 和心脏自主神经病变 (CAN) 代表了与GLMD相关的主要心血管损伤.
研究的目的:
- 审查最近 (2018-2025) 关于将GLMD与心血管损伤联系起来的分子机制的研究.
- 确定ASCVD,DbCM,HF和CAN的关键分子通路和潜在干预措施.
主要方法:
- 针对PubMed,科学网络和EMBASE数据库的有针对性的文献审查.
- 引用跟踪用于识别关键出版物.
- 分析重点是针对GLMD相关心血管并发症的分子途径和干预措施.
主要成果:
- 关键机制包括代谢炎症 (AGEs-RAGE轴),心肌脂毒性 (CD36-cGAS-STING),代谢记忆 (sEV miR-15-16),以及肠心轴障碍 (TMAO).
- 精确的策略,如SGLT2抑制剂,ACBP/TGR5向和微生物群调节,显示出临床潜力.
结论:
- 了解这些分子机制对于开发向疗法至关重要.
- 未来的研究应侧重于GLMD异质性,组织向传递,以及针对个性化心血管护理的多主题AI风险建模.
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