宫内生长限制与慢性病之间的关联:一个出生队列研究分析分析
Daniela Aparecida Lorencini1, Paulo Cesar Lopes1, Heloísa Bettiol2
1Internal Medicine Department, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
Kidney medicine
|November 10, 2025
概括
宫内生长限制 (IUGR) 会增加慢性病 (CKD) 的风险,特别是在女性中. 在这项出生队列研究中,低出生体重和早产与CKD风险没有显著的关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 发展生物学 发展生物学
- 流行病学 流行病学
背景情况:
- 慢性病 (CKD) 是一个主要的健康问题,糖尿病和高血压是主要的危险因素.
- 胎儿发育因素,包括低出生体重 (LBW),子宫内生长限制 (IUGR) 和早产,越来越多地被认为是导致晚年功能下降的因素.
- 了解这些与出生有关的疾病的长期影响对于早期干预和预防策略至关重要.
研究的目的:
- 调查胎儿生长条件 (IUGR,LBW,早产) 与生命第三十年发展CKD的风险之间的联系.
- 为了评估这些出生暴露对功能标记物的影响,具体估计了球过率 (eGFR) 和尿白蛋白-肌素比率 (UACR).
主要方法:
- 在巴西进行了一项单中心分娩队列研究,在1978-1979年期间招收了6827名新生儿.
- 分析了2016-2017年1564名参与者的随访数据.
- 使用统计模型,包括多变量线性回归,量子力回归和逻辑回归来评估出生暴露与CKD结果之间的关系.
主要成果:
- 宫内生长限制 (IUGR) 与CKD的更高患病率 (25.3%与18.1%) 和CKD风险增加 (OR 1.50 [1.10-2.21]) 有显著关联.
- 过早生育与略低的eGFR有关,但在多变量分析中,无论是LBW还是过早生育都没有显示出与CKD风险的显著关联.
- 女性性别,高血压,糖尿病和高C反应性蛋白水平等因素与CKD风险增加或功能标志物较差有关.
结论:
- 宫内生长限制 (IUGR) 是晚年患慢性病 (CKD) 的重要危险因素,特别是在女性中.
- 虽然早产和LBW与该队列中CKD风险增加没有直接联系,但IUGR强调胎儿发育在长期脏健康中的关键作用.
- 这些发现强调了监测具有IUGR病史的个体对功能的重要性.
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