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在患有急性淋巴细胞白血病的儿童中,皮层形态变化和结构共变网络拓的变化

Ke Wei^1,2, Ruiyuan Chen², Zhixin Gao²

¹Radiology Department, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Quantitative imaging in medicine and surgery

|November 10, 2025

概括

化疗改变了急性淋巴细胞白血病 (ALL) 的儿童的大脑结构,导致皮层变薄和网络变化. 额叶似乎是受影响最严重的,这表明在治疗期间大脑的早期重组.

科学领域:

神经科学是一个神经科学.
儿科瘤学儿科瘤学
医疗成像医学成像

背景情况:

化学疗法诱导的认知障碍 (CICI) 机制以及儿科急性淋巴细胞白血病 (ALL) 中相关的大脑变化尚不清楚.
早期化疗引起的皮质形态变化和ALL儿童的结构共变性网络 (SCN) 重组需要调查.

研究的目的:

研究早期化疗引起的皮质形态变化的研究.
在接受ALL化疗的儿童中检查结构共变性网络 (SCN) 的重组.

主要方法:

基于表面的形态测量 (SBM) 用于评估26名患有ALL的儿童的皮质形态变化.
统计分析包括配对的t测试,对形态变化进行家族智能错误 (FWE) 校正.
全球和本地SCN参数用假发现率校正的顺序测试来计算和分析.

主要成果:

在化疗的46-52天,在多个大脑区域观察到显著的皮层稀释.
双侧额叶和右侧岛叶的缩指数减少;左下部中部额叶回形的碎形尺寸减少.
发现左补充运动区域的网络度 (Deg) 增加,左前骨的间距 (Bet) 减少.

结论:

大脑皮层形态和SCN拓性质 (Deg,Bet) 的早期变化在化学疗法期间存在于ALL的儿童中.
双侧额叶可能是该儿科人群中CICI最容易受到影响的大脑区域.
观察到的拓性质变化表明,在化疗后,大脑网络结构内存在潜在的补偿性重组.

关键词:

急性淋巴细胞白血病 (ALL)化疗引起的认知障碍 (CICI)磁共振成像 (MRI) 的使用.结构共变网络 (SCN) 是一个结构共变网络.基于表面的形态测量 (SBM)

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