超性心肌病症中QRS持续时间和左心室变形之间的关系
Shi Chen1, Mingxuan Duan2, Xi Zhao2
1Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Quantitative imaging in medicine and surgery
|November 10, 2025
概括
在高性心肌病 (HCM) 中,延长QRS持续时间与左心室 (LV) 功能受损相关. 这表明QRS持续时间可以表明阻塞性和非阻塞性HCM中的特定变形模式.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 电子生理学 电子生理学
背景情况:
- QRS 持续时间是高缩性心肌病 (HCM) 中心室节律失常的已知危险因素.
- 它与不同HCM亚型的左心室 (LV) 功能和形态的关联仍然不清楚.
- 这项研究调查了QRS持续时间与LV菌株的关系,用于高性非阻塞性心肌病 (HNCM) 和高性阻塞性心肌病 (HOCM).
研究的目的:
- 检查QRS持续时间和LV全球和细分应变值之间的相关性.
- 确定QRS持续时间是否可以作为HNCM和HOCM患者LV功能障碍的指标.
- 在HNCM与HOCM中区分与延长QRS持续时间相关的变形模式.
主要方法:
- 对45名HNCM和81名HOCM患者的回顾性分析,这些患者有保存的喷射分数.
- 通过标准的12导电心电图测量QRS持续时间.
- 使用心脏磁共振特征追踪评估的LV全球和细分菌株.
主要成果:
- 在HNCM患者中,QRS持续时间与全球周边,辐射和纵向应变相关.
- 在HOCM患者中,QRS持续时间与全球环形和辐射应变相关.
- 在QRS持续时间≥110毫秒的患者中,在HNCM中表现出全球辐射应变受损和缩/透缩应变率峰值,在HOCM中表现出周围应变和应变率降低. 延长的QRS持续时间表明HNCM的顶峰变形和HOCM的中壁参与.
结论:
- QRS持续时间与HNCM和HOCM的全球和细分LV减值有关.
- 延长的QRS持续时间可能表明LV变形的特定模式,例如HNCM中的顶点参与和HOCM中的中壁变化.
- QRS持续时间作为一个潜在的非侵入性标记,用于评估HCM中的LV功能和形态.
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