基于voxel的形态测量揭示了大脑小血管疾病中的灰质缩:与认知障碍的相关性
Chaoying Qi1, Xia Liu1, Li Liu2
1Department of Radiology, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou Medical University, Jinzhou, China.
Quantitative imaging in medicine and surgery
|November 10, 2025
概括
脑小血管疾病 (CSVD) 认知障碍 (CI) 患者在特定的大脑区域显示灰质体积 (GMV) 减少. 结合CSVD得分,中叶缩 (MTA) 和右桃体GMV的组合模型最好预测CI.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 大脑小血管疾病 (CSVD) 是认知障碍 (CI) 的常见原因之一.
- 在CSVD患者中早期发现CI对于及时干预至关重要.
- 在CSVD-CI中微观结构性大脑变化需要进一步调查.
研究的目的:
- 为了研究和比较灰质体积 (GMV) 微观结构在CSVD患者和没有CI的神秘变化.
- 确定CSVD相关认知障碍 (CI) 的潜在标志物.
- 帮助临床医生在CI的早期诊断.
主要方法:
- 基于voxel的形态测量 (VBM) 用于分析52名CSVD-CI患者和48名CSVD-正常认知 (CSVD-NC) 患者的3D-T1WI图像.
- 统计比较包括学生的t测试和皮尔森的千平方测试.
- 进行了相关性分析和接收器操作特征 (ROC) 曲线分析,以评估GMV变化与认知功能之间的关系.
主要成果:
- 在CSVD-CI患者中,左侧和右侧舌环,丘脑的背核和右桃体的GMV显著降低.
- 左舌环和右舌环的灰质缩与注意力领域的相关性最强.
- 右杏仁体的GMV变化与延迟的记忆和注意力有关;质体的GMV变化与定向和语言缺陷有关.
结论:
- 结合修改的CSVD得分,中叶缩 (MTA) 和右桃体GMV的综合模型在CSVD患者中显示了CI的最高预测值 (AUC=0.801).
- 该模型有助于检测CSVD中与CI相关的微结构变化.
- 这些发现提供了一个更全面的方法来识别CSVD患者的CI.
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