相关实验视频

Updated: Jan 11, 2026

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

坚持珠子:使用ChemBeads超级充电药物化学和方法开发

Noah P Tu¹, Ying Wang¹

¹AbbVie Inc. 1 N. Waukegan Rd North Chicago Illinois 60064 USA noahtu@hotmail.com.

RSC medicinal chemistry

|November 10, 2025

概括

作为固体试剂输送平台的ChemBeads克服了自动化化学实验的挑战. 这项创新简化了高通量实验和药物化学,加速了合成方法的开发.

科学领域:

化学工程是化学工程的重要组成部分.
药用化学医学化学
材料科学材料科学材料科学

背景情况:

微型化和自动化化学实验面临着试剂处理方面的挑战.
流动不良的粉末阻碍了高通量实验 (HTE) 中高效的机器人和手动配剂.

研究的目的:

探索ChemBead作为固体试剂输送平台的开发,制备和应用.
为了展示ChemBead如何在微型化工过程中克服材料处理的挑战.

主要方法:

化学珠子是通过在惰性载体珠子上干涂活性试剂来制备的.
响应声学混合 (RAM) 或旋混合使粉末能够转化为可流动材料.
研究了光氧催化,交叉电友合,C-N和C-H功能化以及晚期氧化中的应用.

主要成果:

化学颗粒提供了统一的,可流动的材料,与自动和手动配剂系统兼容.
简化了HTE和药物化学工作流程,加速了合成方法的开发.
在各种化学转换中成功应用,包括催化和功能化.

结论:

ChemBead技术有效地解决了小型化化学实验中的材料处理问题.
该平台加速了新合成方法的开发,并促进了行业和学术界的合作.
通过扩展到生物催化剂,可溶性试验和固体形式选来证明适应性.

更多相关视频

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications

Published on: September 23, 2013

Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization

Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization

Published on: February 27, 2020

相关概念视频

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...