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Updated: Jan 11, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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对生物异构体替代品的数据驱动评估及其对非目标活动概况的影响

Palle S Helmke1, Julia Kandler1, Sara Ilie1

  • 1University of Vienna, Department of Pharmaceutical Sciences Vienna Austria gerhard.f.ecker@univie.ac.at.

RSC medicinal chemistry
|November 10, 2025
PubMed
概括

生物异构体替代剂显著改变药物的效力,以为胺的变化降低了CHMR2的活性,而为兰在ADORA2A增加了活性. 这种系统分析有助于优化候选药物,通过预测功效转移和选择性来优化药物候选物.

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