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新生儿败血症中的代谢学:对当前证据的批判性评估

Aliya Baizhanova1, Zhalaliddin Makhammajanov2, Dinara Galiyeva1

  • 1Department of Medicine, School of Medicine, Nazarbayev University, Astana Z05K4F4, Kazakhstan.

Computational and structural biotechnology journal
|November 10, 2025
PubMed
概括

代谢学显示出通过识别改变的代谢物来诊断新生儿败血症的前景. 然而,需要进行更多的标准化研究,以克服当前对这种关键疾病的生物标志物发现的局限性.

关键词:
代谢学 代谢学 代谢学新生儿败血症 新生儿败血症奥米克斯技术技术的使用.败血症 这是一种败血症.

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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