量化评估的年龄相关的肺结构变化:在中国男性队列中的横截面研究
Meijuan Shi1, Youmin Guo2, Chenwang Jin2
1Department of Radiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Frontiers in aging
|November 10, 2025
概括
肺老化表现出非线性结构变化,肺气泡指数和气道到肺的比率在叶片之间有所不同. 一个新的肺年龄评分有助于评估这些与年龄相关的肺部变化.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 老年学是一门学科.
背景情况:
- 与年龄相关的肺结构变化是复杂的.
- 了解这些变化对于诊断和管理肺部疾病至关重要.
研究的目的:
- 通过使用定量CT参数来研究肺结构与年龄相关的变化.
- 开发一个计算公式来评估结构性肺衰老.
主要方法:
- 从肺结节查队列中对928名男性受试者的回顾性分析.
- 计算了定量CT参数,包括肺体积 (LV),平均病变密度 (MLD),肺指数 (LAA-910,LAA-910%,LAA-950,LAA-950%),支气管数 (NB),支气管体积 (VB) 和气道到肺的比率 (ALR).
- 分析了整个肺,右/左肺和个别叶的参数.
主要成果:
- 肺部体积和支气管体积在老年人群中达到顶峰.
- 平均病变密度随着年龄的增长而下降,而肺瘤指数和气道到肺的比率增加.
- 在右肺和左肺以及上和下叶之间观察到显著的差异,上叶显示肺体积增加,下叶显示肺体积和密度随着年龄的增长而减少.
- 一个计算公式,LungAge评分,被开发用于评估结构性肺衰老.
结论:
- 肺衰老是一个非线性过程.
- 在上下叶之间的肺结构变化中存在显著的异质性.
- 肺年龄评分为量化与年龄相关的肺结构变化提供了一种新的方法.
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