预防,精准预防和精准医学.
1School of Public Health, Imperial College, London, United Kingdom.
Exposome
|November 10, 2025
概括
曝光体或曝光型为精准医学提供了潜力,但需要对实际预防进行批判性评估. 税收和疫苗接种等人口层面的干预措施仍然是高效和成本效益的公共卫生战略.
科学领域:
- 公共卫生 公共卫生
- 环境健康 环境健康
- 精准医学是一门精准的医学.
背景情况:
- 暴露组 (异型) 的概念补充了基因型,旨在推进精准医学和初级预防.
- 整合技术,如omics,电子健康记录和人工智能到公共卫生是有吸引力的.
- 然而,暴露组方法对于精确预防的实用性需要进行批判性检查.
研究的目的:
- 批判性地评估用于精确预防的暴露组方法的应用.
- 评估使用exotype的实际要求和限制.
- 将以个人为中心的精确预防与人口层面的公共卫生干预进行对比.
主要方法:
- 对现有提案和技术进行评论和批判性分析.
- 检查对在异型测量中因果关系所需的证据.
- 在医疗保健中实施外型测量的经济考虑.
主要成果:
- 预防的实践应用需要强有力的因果关系证明.
- 暴露型的附加值可能是有限的,特别是当考虑诸如治疗所需人数 (NNT) 等指标时.
- 对医疗保健系统来说,测量表现型的成本,特别是用omics数据,可能是无法承受的.
结论:
- 通过exposome精确预防面临因果关系,成本和实用性方面的挑战.
- 公共卫生的成功往往是由结构性,社会干预 (如税收,疫苗接种) 而不是单独的个人责任驱动的.
- 人口层面的预防策略比个性化方法更具成本效益,更广泛适用,更可持续,不应该被精确预防建议所掩盖.
更多相关视频
13:24Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
12.2K
07:03Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
Published on: December 1, 2023
1.4K
相关概念视频
Preventive Healthcare Services
1.8K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.8K
Combination Therapies and Personalized Medicine
5.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.9K
Levels of Health Promotion and Illness Prevention
14.1K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
14.1K
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Accuracy and Precision
13.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate...
13.9K
