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对Butyricicoccus faecihominis的安全评价 DSM 3494343 DSM 3494343 的安全评价

Jeffrey Pitt¹, Mark R Bauter², Ritesh Kumar³

¹Roquette America, Inc., Larkin Laboratory, 1803 Larkin Center Drive, Midland, MI 48642, USA.

Toxicology reports

|November 10, 2025

概括

一种新的人类肠道细菌,Butyricicoccus faecihominis DSM 34943,在90天的老鼠研究中被发现是安全的. 这种益生菌显示出改善小鼠代谢健康的潜力.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
毒理学毒理学毒理学

背景情况:

一种新型菌株,Butyricicoccus faecihominis DSM 34943,从人类便中分离出来.
对于新型益生菌候选人来说,全面的安全评估至关重要.

研究的目的:

评估B. faecihominis的安全性和潜在疗效DSM 34943.
通过亚慢性毒性研究来确定无观察效应水平 (NOEL).

主要方法:

基因组评估,体外表征 (抗生素敏感性,胆汁/胃汁耐受性),以及体内28天和90天的小鼠毒性研究.
在饮食诱导肥胖 (DIO) 鼠标模型中的评估.

主要成果:

B. faecihominis DSM 34943 没有表现出毒性因素,对抗生素和胃肠道疾病敏感.
在大鼠中没有观察到高达2000mg/kgBW/天的毒性或转位90天,以确定在这个极限剂量时的NOEL.
在DIO小鼠中补充剂改善了胰岛素敏感性和代谢标志物 (勒素,抵抗素,胆固醇).

结论:

B. faecihominis DSM 34943是一种安全的菌株,在动物模型中没有观察到毒性.
这种菌株显示出作为下一代益生菌增强代谢健康的潜力.

关键词:

B. faecihominis DSM 3494343 这种虫子是什么意思基因组安全性基因组安全性益生菌益生菌益生菌它们是老鼠,老鼠,老鼠.安全的安全的安全的安全的安全.亚慢性毒性亚慢性毒性

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