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Updated: Apr 12, 2026

Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction
09:25

Do's and Don'ts of Cryo-electron Microscopy: A Primer on Sample Preparation and High Quality Data Collection for Macromolecular 3D Reconstruction

Published on: January 9, 2015

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通过Cryo-EM和AI进行高分辨率蛋白质建模:当前的趋势和未来的前景 - - 综述

Gnanaprakash Jeyaraj1, Anith Kumar Rajendran2, Kuppusamy Sathishkumar3

  • 1Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

Frontiers in molecular biosciences
|November 10, 2025
PubMed
概括

最近冷电子显微镜 (cryo-EM) 和人工智能 (AI) 的进展正在彻底改变蛋白质结构的确定. 这种融合加速了对蛋白质功能的理解,并有助于药物发现.

关键词:
阿尔法折叠是什么意思阿尔法折叠人工智能的人工智能是人工智能.冷电子显微镜的使用方法蛋白质结构预测 蛋白质结构预测结构生物学结构生物学

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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