血清和尿液代谢指纹使IgA脏病的诊断和预后成为可能
Beili Wang1, Ruimin Wang2, Wenqi Shao1
1Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Materials today. Bio
|November 10, 2025
概括
一种使用血清和尿液代谢分析的新型非侵入性方法,有助于早期IgA病 (IgAN) 的诊断和预后. 这种方法对精确的IgAN管理有希望,克服了活检的局限性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物化学 生物化学
- 计算生物学 计算生物学
背景情况:
- IgA脏病 (IgAN) 是最常见的血球膜炎,在20%-40%的患者中具有显著的地理差异和进展到末期脏病.
- 目前的诊断依赖于侵入性脏活检,强调了对非侵入性诊断和预后工具的需求.
研究的目的:
- 开发和验证一种双流体代谢分析方法,用于IgA脏病的早期,非侵入性诊断和预后评估.
- 评估代谢分析对追踪疾病进展和治疗反应的有用性.
主要方法:
- 使用纳米粒子增强激光脱吸/电离质谱法 (NPELDI-MS) 来对血清和尿液样本进行代谢指纹检测.
- 集成的机器学习算法来分析代谢数据以进行诊断和预后能力.
- 在治疗期间跟踪关键代谢物的动态变化,以确定不同的代谢途径.
主要成果:
- 开发的模型实现了高诊断性能 (AUC = 0.81-0.95) 在Igan患者与健康对照区分.
- 在不同的预后亚组中,确定了不同的代谢途径,表明了个性化治疗策略的潜力.
- 代谢剖析在监测疾病状况和对治疗的反应方面表现出有效性.
结论:
- 双流体代谢分析与机器学习相结合,为IgA脏病的早期诊断和预后评估提供了一个有希望的非侵入性策略.
- 这种方法可以帮助精确管理Igan,可能减少对侵入性脏活检的依赖.
相关概念视频
01:26Nephrotic Syndrome II : Assessment and Medical Management
187
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
187
01:24Serum Studies: Renal Function Tests
354
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
354
01:29Urine Studies I: Urinalysis
1.1K
Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
1.1K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
254
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
254
01:28Chronic Kidney Disease III: Interprofessional Care
331
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
331
01:30Serum Laboratory Studies, Stool Test, Breath Test
738
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
738