一个免疫疗法诱导的平衡炎病例
Terrence Sun1, Danielle Brazel1, Aditya Sarvaria1
1Hematology and Medical Oncology, Scripps Clinic, San Diego, USA.
Cureus
|November 10, 2025
概括
布罗利祖马布免疫疗法可能导致平衡炎,这是一个罕见但严重的皮肤反应. 本案例报告证明了局部药物治疗的成功,允许继续癌症治疗和副作用的管理.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法,特别是免疫检查点抑制剂,如 pembrolizumab,是癌症治疗的基石.
- 虽然有效,但这些疗法可以诱导一系列与免疫相关的不良事件,包括皮肤毒性.
- 严重的皮肤反应,虽然比皮肤炎少见,但需要仔细监测和管理.
研究的目的:
- 报告一个由 pembrolizumab 诱导的平衡炎病例.
- 审查与癌症免疫治疗相关的常见皮肤毒性.
- 讨论平衡炎的病因和治疗策略.
主要方法:
- 案例报告的呈现方式.
- 对免疫疗法诱导的皮肤学不良事件的文献综述.
- 审查平衡炎的原因和治疗方法.
主要成果:
- 在 pembrolizumab 治疗期间,一名患者发病了平衡炎.
- 使用局部类固醇奶油和mupirocin膏,平衡炎得到了成功的管理.
- 治疗成功不需要停止 pembrolizumab.
结论:
- 布罗利祖马布可以作为免疫相关的不良事件引起平衡炎.
- 局部治疗可以有效地管理免疫疗法诱导的平衡炎.
- 成功管理平衡炎,可以不间断地治疗癌症.
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