在老年人中,严重的萨尔科佩尼亚与认知衰退的组件的关联:一个横截面研究
Nishant Roy1, Debabrata Brahma1, Anup Singh1
1Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.
Cureus
|November 10, 2025
概括
在患有严重的肉症的老年人中,步行速度和握力是认知功能的关键指标,比肌肉质量更重要. 这些简单的身体评估可以帮助早期发现认知能力下降.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 运动学 运动学
背景情况:
- 标志着肌肉质量损失和肌肉衰弱的萨尔科佩尼亚会影响老年人.
- 肌肉力量和步行速度与认知有关,但肌肉质量在严重的肉症中的作用尚不清楚.
- 认知障碍在老年人群中越来越令人担忧.
研究的目的:
- 为了检查尾骨肌肉质量 (ASM),手握力 (HGS) 和步行速度 (六米步行测试,6MWT) 与认知功能 (印度语迷你精神状态检查,HMSE) 之间的关联,在患有严重肉症的老年人中.
- 确定 sarcopenia 的哪个组成部分是这个人群中认知表现最强的预测因素.
主要方法:
- 40名成年人 (≥60岁) 患有严重的肉症和低HMSE分数的横截面研究.
- 通过HMSE评估认知功能;通过生物电阻测量ASM;用动力计测量HGS;使用6MWT测量步行速度.
- 使用皮尔森的相关性和多重回归分析来评估关联.
主要成果:
- 尾骨肌量 (ASM) 和六米步行测试 (6MWT) 步行速度与HMSE分数 (p=0.032和p<0.001分别) 呈正相关性.
- 手握强度 (HGS) 显示出一个积极的趋势 (p=0.07).
- 多变量分析显示,步行速度 (β=0.78,p<0.001) 和HGS (β=0.40,p=0.002) 是HMSE的显著预测因素,而ASM则是较弱的预测因素 (β=0.25,p=0.034).
结论:
- 步行速度和手握强度是认知能力下降的更显著的预测因素在老年人严重的肉比尾骨肌肉质量.
- 简单的身体功能测试,如步行速度和握力,可以帮助在这个人口中早期识别认知障碍.
- 糖尿病,甲状腺功能低下和慢性脏病等并发症会对严重的人的认知功能产生负面影响.
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