血液系统性炎症标志物与Helicobacter pylori感染患者的焦虑之间的关联
Jiantao Gong1, Fengjuan Chen1, Bin Jiang1
1Department of Gastroenterology, Xishan People's Hospital of Wuxi City, Wuxi, China.
Frontiers in psychiatry
|November 10, 2025
概括
慢性Helicobacter pylori感染与焦虑有关. 系统性炎症标志物,包括系统性炎症总指数 (AISI),可能有助于对H. pylori患者的焦虑进行查.
科学领域:
- 胃肠病学和精神病学 在
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 慢性Helicobacter pylori (H. pylori) 感染与胃肠道症状,全身炎症和焦虑症等精神疾病有关.
- 早期的焦虑查对H. pylori患者至关重要,因为精神干预可以改善治疗结果.
- 这项研究调查了在H. pylori阳性个体中检测焦虑的潜在生物标志物.
研究的目的:
- 为了确定潜在的生物标志物,以检测H. pylori阳性个体的焦虑.
- 评估这些生物标志物与焦虑症状之间的关系.
- 探索系统性炎症在与H. pylori感染相关的焦虑发展中的作用.
主要方法:
- 160名参与者 (81名H.pylori阳性,79名H.pylori阴性) 接受了神经心理评估和血液采集.
- 系统性炎症指数 (SII,SIRI,AISI) 从常规的血液学参数计算出来.
- 使用汉密尔顿焦虑量表 (HAMA) 和自我评价焦虑量表 (SAS) 来评估焦虑程度.
主要成果:
- 与H.pylori阴性患者相比,H.pylori阳性患者的焦虑评分 (HAMA,SAS) 和炎症标志物 (SII,SIRI,AISI) 的增加较高.
- 系统性炎症的综合指数 (AISI) 显示了感染状态的最佳诊断准确性 (AUC=0.746),其次是SIRI和SII.
- 在H. pylori阳性患者中,炎症标志物与焦虑评分和质纤维酸蛋白 (GFAP) 水平相关,GFAP调解了这种关系.
结论:
- 系统性炎症指数与H. pylori感染的个体中焦虑的发展有关.
- 这些炎症标志物,特别是AISI,SIRI和SII,显示出在这个人群中用于焦虑查的实用生物标志物的潜力.
- 质纤维酸蛋白 (GFAP) 在H. pylori阳性患者的全身炎症和焦虑症状之间的关联中起着调解作用.
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