冠状动脉样硬化中同类代谢途径的诊断价值:对参考间隔和风险预测的研究
Shen Li1, Furong Zhao2, Mo Hong3,4
1Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, People's Republic of China.
International journal of general medicine
|November 10, 2025
概括
确定同类氨酸 (Hcy),氨酸 (Cys) 和氨酸 (Met) 的参考间隔有助于冠状动脉样硬化 (CA) 风险评估. 这些代谢物是独立的风险因素,改善CA诊断和预测准确度.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 临床化学 临床化学
背景情况:
- 冠状动脉硬化 (CA) 风险评估需要准确的诊断工具.
- 同型氨酸 (Hcy) 代谢途径,包括氨酸 (Cys) 和氨酸 (Met),与心血管健康有关.
- 为这些代谢物建立可靠的参考间隔对于临床应用至关重要.
研究的目的:
- 在健康成年人中确定同类氨酸 (Hcy) 代谢途径的参考间隔.
- 探索Hcy,Cys和Met水平与冠状动脉样硬化 (CA) 之间的相关性.
- 为了提高CA的风险评估和诊断准确性,使用Hcy代谢途径标记物.
主要方法:
- 直接连续采样用于招募426名健康成年人进行基准区间的确定.
- 使用LC-MS/MS分析了Hcy,Cys和Met的血清水平.
- 包括75名被诊断为CA的患者,以评估与代谢物水平的相关性.
主要成果:
- 确定了参考间隔:Hcy 7-25 μmol/L,Cys 227-410 μmol/L,以及Met 21-39 μmol/L. 这些都是指标.
- 两性之间观察到Met和Hcy水平的显著差异,但不符合单独参考间隔的标准.
- Hcy,Cys和Met被确定为CA的独立风险因素,其AUC组合值为0.86,敏感度为78%,特异性为83%.
结论:
- Hcy代谢途径为癌症诊断和风险预测提供了有价值的参考值.
- 使用Hcy,Cys和Met水平显著提高了CA风险评估的能力.
- 这一途径为改善冠状动脉样硬化的诊断准确性提供了一个有希望的方法.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
525
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
525
01:30Coronary Artery Disease I: Introduction
863
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
863
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
450
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
450
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
377
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
377
01:26Coronary Artery Disease IV: Preventive Measures
578
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
578
01:30Acute Coronary Syndrome III: Diagnostic Studies
200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200