在初级肺癌手术中,炎症指数对术后并发症的预测效用有限
Muharrem Özkaya1, Nilay Çavuşoğlu Yalçın1, Erhan Özyurt2
1Department of Thoracic Surgery, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye.
系统性炎症指数,如泛免疫炎症值 (PIV),系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI),无法有效预测肺癌手术患者的早期术后并发症. 为了更好的预测标记物,需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 外科手术的结果
- 炎症标记物 炎症标记物
背景情况:
- 系统性炎症指数 (泛免疫性炎症值 - PIV,系统性免疫性炎症指数 - SII,系统性炎症反应指数 - SIRI) 是已知的癌症预后标志物.
- 它们在预测肺癌手术后的早期术后并发症方面的实用性尚未得到充分证实.
研究的目的:
- 评估PIV,SII和SIRI在肺癌手术后早期术后并发症的预测性表现.
- 评估这些炎症指数与30天并发症之间的关联.
主要方法:
- 对68名为原发性肺癌进行肺切除的患者的回顾性分析.
- 使用手术前和手术后第一天的血液样本计算PIV,SII和SIRI.
- 比较统计和接收器操作特征 (ROC) 分析,以评估与30天并发症的关联.
主要成果:
- 14.7%的患者经历了30天的并发症.
- 在有并发症和没有并发症的患者之间没有观察到PIV,SII或SIRI的显著差异.
- 对所有指数的ROC分析表明预测性表现不佳 (AUC范围:0.447-0.612).
结论:
- 已建立的预后炎症指数 (PIV,SII,SIRI) 显示,在肺癌手术中预测早期术后并发症的能力有限.
- 这些发现表明,在肺癌的外科手术期间,对这些指数进行谨慎的解释.
- 需要进行前性研究,以确定多式联运模式的替代预测标记.
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