丹塞诱导的心脏骤停和心肌病与成功逆转:一个案例报告
Rawan Tafish1,2, Ramy Elsayed3, Sami Alsolamy4
1Department of Clinical Pharmacy, SMC Hospital, Riyadh, Saudi Arabia.
AME case reports
|November 10, 2025
概括
丹塞是一种抗药,即使在健康人群中,也可能导致严重的心脏事件,如心脏骤停和心肌病变. 及时干预和电解质管理对于患者的康复至关重要.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 丹塞是一种5-基三胺3 (5-HT3) 受体对抗剂,是一种广泛使用的抗emetic.
- 美国食品和药物管理局 (FDA) 警告称,丹塞可能导致QT间隔延长,增加心律失常风险.
- 这种风险在患有先前心脏病的患者中尤其令人担忧.
研究的目的:
- 报告一种罕见的心脏骤停和心肌病变的病例,该病例发生在一次静脉注射Ondansetron剂量后.
- 要强调考虑丹塞的心脏副作用的重要性,即使在没有病史的患者中也是如此.
- 为了强调电解质平衡在Ondansetron诱导的心脏事件中的作用.
主要方法:
- 一个43岁的女性患者经历了心脏骤停后的病例研究ondansetron管理.
- 包括患者的病史,实验室发现 (低血,低血,低血) 和心脏事件 (心室动,torsade de pointes).
- 临床干预的描述,包括心肺复苏 (CPR),重症监护室 (ICU) 管理,电解质失衡和左心室 (LV) 功能障碍的治疗.
主要成果:
- 患者经历了心脏骤停,心室动,torsade de pointes,和心肌病仅仅在一次IVondansetron剂量后.
- 电解质失衡 (低磁血症,低血症,低) 被确定为导致因素.
- 经过密集的医疗干预和电解质干扰管理,患者经历了完全康复.
结论:
- 由于可能发生严重的心脏事件,包括心脏骤停和心肌病变,Ondansetron的使用需要谨慎.
- 电解质不平衡是丹相关心律不整的重要危险因素.
- 临床医生必须保持警,注意丹塞引起的心脏并发症,并实施预防措施,特别是在高危人群中.
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