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"不那么沉默"的神经内分泌新生瘤:两例胃肠小细胞神经内分泌癌的病例报告

Ali Dashti¹, Hyun Jae Kim¹, Andrew Fetz¹

¹Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

AME case reports

|November 10, 2025

概括

胃肠道的小细胞神经内分泌癌 (SCNECs) 是罕见的和积极的. 这些案例研究突出了诊断挑战和积极的进展,强调了对胃和直肠SCNECs更好的协议的需要.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

胃肠道的小细胞神经内分泌癌 (SCNEC) 是罕见的和具有攻击性的.
肺外的GI-SCNEC缺乏标准化的诊断途径和治疗,因为它们很罕见,并与其他瘤重叠.
关于GI-SCNECs的临床过程和特定场所表现的文献有限.

研究的目的:

报告两个截然不同的GI-SCNECs病例.
为了强调诊断挑战和积极的临床进展.
强调需要标准化的诊断标准和治疗方案.

主要方法:

两名患有SCNECs的患者的病例报告.
通过内镜活检确认诊断.
记录了临床过程和治疗反应.

主要成果:

案例1:80岁的男性患有胃SCNEC,扩散转移,在一个月内死亡.
案例2:69岁的男性患有直肠SCNEC,肝脏和结节转移,通过化疗和放射治疗实现了暂时稳定,在11个月内死亡.
两例病例都显示,尽管进行了干预,但疾病的进展仍然很激烈.

结论:

在快速进展的胃肠道恶性瘤中,对SCNEC的临床怀疑是必要的.
早期识别和多学科管理至关重要,但具有有限的持久性.
对GI-SCNECs的标准化诊断标准和治疗方案需要进一步的研究.

关键词:

小细胞癌小细胞癌.案例报告案例报告胃潰瘍胃潰瘍胃潰瘍胃肠道神经内分泌癌 (GI-NEC)这是直肠质量.

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