基于人工智能的药物基因相互作用预测,调节紧结完整性:一个深度学习框架,突出多个治疗点
Varun Keskar1, Amrutha Shenoy1, Shreya Desai1
1Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Technical and Medical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Journal of oral biology and craniofacial research
|November 10, 2025
概括
这项研究引入了一个AI框架来预测药物如何影响紧密的结点,这对屏障功能至关重要. 该模型准确地识别了潜在的候选药物,如Cimifugin,用于治疗与紧结扰乱相关的疾病.
科学领域:
- 生物技术是生物技术.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 紧密的结点对于上皮和内皮壁垒的完整性至关重要.
- 紧张结节的功能障碍与炎症性肠道疾病,喘和癌症等疾病有关.
- 识别调节紧结功能的药物对于治疗开发至关重要.
研究的目的:
- 开发一种深度学习框架,用于预测药物诱导的紧结完整性的调制.
- 利用多omics数据来准确预测影响紧密结的药物基因相互作用.
- 确定针对疾病治疗紧密交叉点的新药候选药物.
主要方法:
- 从NCBI GEO预处理的转录基因数据来识别差异表达基因 (DEGs).
- 使用网络分析来提取关键的枢纽基因.
- 训练了一个前神经网络模型,并使用AUC,CA和F1得分等指标评估其性能.
主要成果:
- 神经网络模型实现了高性能,AUC为0.947,CA为0.980,F1得分为0.969.
- 鉴定出cimifugin作为CLDN1的潜在调节剂,同时也指出了Baicalein和Berberine.
- 与传统方法相比,该模型显示出更高的预测能力.
结论:
- 开发的深度学习框架提供了一个可扩展的,数据驱动的方法来预测药物对紧密交叉点的影响.
- 这种基于人工智能的方法促进了药物发现和个性化药物治疗涉及紧密结节破坏的疾病.
- 这项研究突出了潜在的治疗策略,以障碍功能受损为特征的条件.
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