铜 (II) 复合物来源于素替代的希夫基联体:合成,晶体结构,抗菌活性和分子对接研究
Tunde Lewis Yusuf1, Ibrahim Waziri2, Segun D Oladipo3,4
1Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X20, Hatfield, Pretoria 0028, South Africa.
ACS omega
|November 10, 2025
概括
新型铜 (II) 复合物与希夫基联体显示出对抗性细菌具有显著的抗菌活性. 复合物2对阳性菌株表现出强烈的疗效,这表明它是传统抗生素的有希望的替代品.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 抗菌研究 抗菌研究
背景情况:
- 越来越多的细菌耐药性需要新的抗菌剂.
- 金属复合物提供独特的作用机制,可能比有机抗生素副作用更少.
- 希夫基联体是设计生物活性金属复合物的多功能支架.
研究的目的:
- 合成和表征新型铜 (II) 复合物与素替代的希夫基联结体.
- 为了评估这些复合物的抗菌效果对关键的格拉姆阳性和格拉姆阴性细菌.
- 通过分子对接研究来研究作用机制.
主要方法:
- 六个Cu(II) 复合物的合成和特征使用福里埃变换红外,紫外线,元素分析和单晶X射线衍射.
- 通过汁微稀释进行抗菌活性测试,对抗*金黄色葡萄球菌*,*白杆菌 pyogenes*,*大肠杆菌*和*肺炎Klebsiella*.
- 分子对接模拟的目标是托皮索马酶IV受体.
主要成果:
- 所有六个Cu(II) 复合体都成功合成和表征,呈现正方形平面几何.
- 这些复合物表现出一系列的抗菌活性,最小抑制度 (MIC) 在15.63至125μg/mL之间.
- 复合物2对*S. aureus*和*S. pyogenes* (MIC < 15.63 μg/mL) 显示出异常强度,并且对接研究支持了目标亲和力.
结论:
- 合成的铜 (II) 希夫基复合物代表了一类有前途的新型抗菌剂.
- 综合体2显示出对抗格拉姆阳性细菌感染的巨大潜力.
- 这些发现支持使用金属复合物作为对抗抗生素耐药细菌的可行策略.
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