特尔皮宁-4-ol/β-CD液体带的控制释放和抗菌性能
Pairayaphak Ngamplang1, Gulzaib Basharat2, Thanyada Rungrotmongkol2,3
1The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand.
ACS omega
|November 10, 2025
概括
这项研究开发了一种新型的液体带,使用了terpinen-4-ol (T-4-ol) 与β-cyclodextrin (β-CD) 和聚合物的纳入复合物. 增强的配方显示持续释放,抗菌活性,以及组织再生的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 药物输送系统 药物输送系统
背景情况:
- 液体带保护伤口,降低感染风险.
- 特尔皮宁-4-ol (T-4-ol) 具有抗菌和伤口愈合的特性,但由于其物理化学特性,其应用有限.
- 含有β-cyclodextrin (β-CD) 的综合体可以改善药物输送.
研究的目的:
- 开发和描述一种包含T-4-ol/β-CD纳入复合物的新型液体带.
- 研究T-4-ol/β-CD与聚合物矩阵 (PVA/PAA) 之间的相互作用,以优化药物输送.
- 评估开发的液体带的治疗潜力,包括抗菌活性和组织再生.
主要方法:
- 开发T-4-ol/β-CD纳入复合物. 开发T-4-ol/β-CD纳入复合物.
- 一种基于聚乙醇/聚烯酸 (PVA/PAA) 的液体带的配方,其中包含T-4-ol/β-CD.
- 在基分子动力学模拟中分析T-4-ol/β-CD与PVA和PAA的相互作用.
- 实验评估液体带的特性,包括释放动力学,抗菌活性和细胞毒性.
主要成果:
- PVA与T-4-ol/β-CD显示出更强的相互作用 (结合,原子接触),增强了封装和保留.
- PAA表现出较弱的相互作用,有助于pH响应的释放特性.
- 结合T-4-ol/β-CD的液体带显示持续释放超过12小时和显著的抗菌活性.
- 该配方非细胞毒性,并显示有促进组织再生的潜力.
结论:
- 含有T-4-ol/β-CD的复合物有效地增强了基于PVA/PAA的液体带的治疗潜力.
- 不同的聚合物相互作用 (PVA与PAA) 允许控制药物释放和改善化合物保留.
- 开发的液体带是一种有前途的先进伤口护理疗法,具有持续的抗菌和再生特性.
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