生命必不可少的8和肌肉力量在心血管疾病风险上的协同作用
Linlong Li1, Jianhong Xu2, Li Huang1
1Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Frontiers in medicine
|November 10, 2025
概括
较低的肌肉力量增加了心血管疾病 (CVD) 的风险,特别是当与较低的心血管健康评分 (Life) 相结合时.
科学领域:
- 心血管健康 心血管健康
- 衰老研究研究 衰老研究
- 肌肉生理学 肌肉生理学
背景情况:
- 肌肉力量是老年人群中心血管疾病 (CVD) 的已知危险因素.
- 肌肉力量和美国心脏协会 (AHA) 生命必需8 (LE8) 对心血管健康的评分之间的相互作用仍然不清楚.
研究的目的:
- 调查肌肉强度和LE8分数与发生心血管疾病的联合关联.
- 为了确定肌肉强度是否会改变整个LE8得分谱中的心血管疾病风险.
主要方法:
- 分析了来自237,682名个人 (平均年龄55.64岁) 的英国生物库数据.
- 肌肉强度通过握力来评估 (高,中,低三角形).
- LE8分数被分类为理想 (≥80),中等 (50-79) 和低 (<50). 考克斯回归用于检查关节关联和与发生性心血管疾病 (冠心病,心力衰竭,中风) 的相互作用.
主要成果:
- 在平均14.90年的随访期间,记录了26,159起心血管疾病病例.
- 低肌肉强度与具有理想LE8分数的个体的心血管疾病风险无关.
- 在低肌肉强度和低LE8得分之间发现了显著的附加相互作用,导致17%的CVD风险过剩和三倍增加的风险 (HR=3.03).
- 这种协同效应在心力衰竭,女性和年轻人 (<56岁) 中更为明显.
- 血糖显示出与低肌肉强度的增强相互作用最强,其次是睡眠,尼古丁暴露,BMI和体力活动.
结论:
- 与肌肉强度低相关的心血管风险取决于整体心血管健康.
- 低肌肉强度在与心血管健康不佳 (低LE8分) 相结合时构成重大威胁.
- 针对肌肉强度低,心血管健康不佳的个体需要有针对性的干预措施.
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