冠状病毒病2019是否会影响男性生育能力或导致自发流产? 一个双样本的门德尔随机化分析分析
Yufeng Liang1, Xueshan Ma1, Chunli Liu2
1Department of Reproduction and Genetics, The Affiliated Taian City Central Hospital of Qingdao University, No. 29 Long Tan Road, Tai'an, Shandong, 271000, P. R. China.
Open life sciences
|November 10, 2025
概括
这项研究发现,COVID-19感染与男性不孕不育或自发流产之间没有因果关系. 对大型遗传数据集的门德尔随机化分析证实,这些生殖结果不会因SARS-CoV-2感染而增加.
科学领域:
- 生殖健康 生殖健康
- 传染性疾病 传染性疾病
- 遗传流行病学遗传流行病学
背景情况:
- COVID-19 感染引起了人们对生殖健康潜在影响的担忧.
- 了解SARS-CoV-2感染与不良生殖结果 (如男性不育和自发流产) 之间的关系至关重要.
研究的目的:
- 调查COVID-19感染与两个不良生殖结果之间的潜在因果关系:男性不孕不育和自发流产.
- 评估COVID-19的严重程度是否影响这些生殖风险.
主要方法:
- 采用了一个双样本的门德尔随机化 (MR) 研究.
- 来自欧洲祖先种群的全基因组关联研究 (GWAS) 总结统计数据被用于COVID-19表型和生殖结果.
- 多种MR方法,包括逆变量加权 (IVW) 和加权中位数,用于因果推断.
主要成果:
- 在对COVID-19感染的遗传易感性和男性不孕不育之间没有发现显著的因果关系 (OR = 0.7668,p = 0.4590).
- 同样,在COVID-19感染和自发流产之间也没有观察到显著的因果关系 (OR = 0.9936,p = 0.8518).
- 敏感性分析和对COVID-19严重性表型的分析也产生了零结果,表明没有类或异质性.
结论:
- 这项研究提供了强有力的证据,证明COVID-19感染与男性不孕症或自发堕胎风险增加之间的因果关系.
- 研究结果表明,COVID-19不会对这些特定的男性和女性生殖健康结果产生因果关系.
相关概念视频
Infertility in Males
519
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
519
Infertility in Females
3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
3.6K
Randomized Experiments
8.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
8.8K
Regression Toward the Mean
6.8K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.8K
Spermatogenesis
121.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.5K


