竞争性酸阻断剂在功能性消化不良症中的有效性:系统性审查和元分析
Hao The Nguyen1, Arman Vaghefi2, Tassawwar Khan1
1College of Osteopathic Medicine, Rocky Vista University, Parker, CO, USA.
Gastroenterology research
|November 10, 2025
概括
竞争性酸阻断剂 (PCABs) 对功能性消化不良 (FD) 症状缓解有希望. 这次元分析发现PCAB在四周内改善FD症状时具有中等至大效果.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性消化不良 (FD) 是一种常见的胃肠道疾病,导致腹部上部不适.
- FD症状往往对传统的抑制酸性治疗有抗性.
- 竞争性酸阻塞剂 (PCABs) 提供了胃酸抑制的替代方案.
研究的目的:
- 评估PCAB疗法的有效性,以改善FD的成年患者的症状结果.
- 进行对FD的PCAB现有研究的系统审查和元分析.
主要方法:
- 在PubMed,EMBASE和Cochrane CENTRAL的系统文献搜索,截至2025年6月13日.
- 包括随机对照试验和队列研究报告验证的症状得分.
- 用随机效应模型对4周结果的标准化平均差异 (SMD) 进行了聚合.
主要成果:
- 分析了五项涉及366名患者的研究;三项研究 (276名患者) 纳入了元分析.
- 聚合的SMD为1.09 (95%CI:0.67 - 1.52) 表明中度至大治疗效果有利于PCABs在4周后改善症状.
- 观察到实质性的异质性 (I2 = 77.8%),但敏感性分析证实了研究结果的稳定性.
结论:
- PCABs可以为功能性消化不良患者提供显著的症状缓解.
- 研究结果表明PCAB是一种有前途的治疗选择,特别是对于那些对质子抑制剂不反应的人来说.
- 建议进行进一步的安慰剂对照试验,以确认疗效和长期结果.
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