结合CBD/THC用于治疗化疗引起的外围神经病变:一项随机双盲对照试验
Marisa Weiss1,2,3, Muath Giaddui1, Stephanie Kjelstrom1,4,5
1Lankenau Institute for Medical Research, Wynnewood, PA, United States.
在一项小型研究中,大麻素 (CBD) 和delta-9-tetrahydrocannabinol (THC) 显示出改善化疗诱导的周围神经病变 (CIPN) 感官症状的潜力. 需要进一步的研究来证实CIPN治疗的这些发现.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见和衰弱的副作用.
- 目前对CIPN的治疗方法有限,这凸显了对新型治疗方法的需求.
- 临床前研究表明,大麻素 (CBD) 和delta-9-tetrahydrocannabinol (THC) 等大麻素可以缓解神经病变症状.
研究的目的:
- 评估CBD和THC组合在治疗癌症患者中CIPN症状的有效性.
- 评估CBD和THC对CIPN患者感官障碍,疼痛,睡眠和整体功能的影响.
主要方法:
- 一项为期12周的随机,双盲,安慰剂对照试验与患有2-3级CIPN的癌症患者进行.
- 参与者接受了CBD和THC凝囊的组合或安慰剂.
- 主要结果使用"生活质量调查问卷-CIPN20"感官子表进行测量,次要结果包括疼痛,睡眠,功能和神经评估.
主要成果:
- 主要分析显示,CBD/THC组与安慰剂组在整体CIPN症状方面没有显著差异,这可能是由于样本规模较小.
- 第二次分析表明,与安慰剂相比,CBD/THC组在感觉障碍 (QLQ-CIPN20) 中出现了显著改善.
- 在活跃组中观察到轻触感和脚部振动感的改善,接近统计学意义.
结论:
- 虽然主要终点没有达到,但二次分析表明,CBD和THC可能会改善CIPN的感觉方面.
- 对于患有CIPN的患者,CBD和THC的组合被安全地给药.
- 需要更大的,充足的研究来证实CBD和THC对CIPN的治疗潜力.
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