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Updated: Jan 11, 2026

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NNMT编排了代谢-表观遗传重编程,以驱动巨细胞-肌纤维细胞过渡在高伤性痕中

Xiwen Dong1, Weinan Guo2, Yuxuan Qian2

  • 1Department of Dermatology, Air Force Medical Center, Beijing, 100039, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 10, 2025
PubMed
概括

这项研究揭示了一种来自巨细胞过渡的高性痕肌纤维细胞的新来源. 向尼古丁胺N-甲基转移酶 (NNMT) 显示出治疗纤维性疾病的潜力.

关键词:
过度化的痕 (HS)巨细胞 - 肌纤维细胞过渡 (MMT)尼古丁胺N-甲基转移酶 (NNMT) 的使用配对相关的本地盒 (PRRX1)

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