日本系统性硬化症患者的多中心,前性注册表:基线患者特征
Masataka Kuwana1,2, Shinji Watanabe1, Tohru Takeuchi3
1Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan.
Modern rheumatology
|November 10, 2025
概括
这份由835名系统性硬化症 (SSc) 患者组成的日本注册表揭示了关键基线特征. 这些发现突出了常见器官的参与,如间歇性肺病和不同的自身抗体概况,为现代的SSc治疗策略提供了信息.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床研究 临床研究
背景情况:
- 系统性硬化症 (SSc) 管理已经发展,需要更新现实世界的数据.
- 了解基线特征对于评估SSc.当代治疗疗效至关重要.
研究的目的:
- 为日本的SSc患者建立一个有前景的多中心注册表.
- 在当代日本SSc队列中描述基线人口统计,器官参与,自身抗体概况和患者报告的结果.
主要方法:
- 来自20个日本医疗中心的成年SSc患者的潜在招生.
- 通过专门的电子数据捕获系统收集基线数据.
- 包括人口统计,器官表现,自身抗体状态和患者报告的结果.
主要成果:
- 835名符合条件的患者:主要是女性 (85.1%),中位数年龄为64岁,35.0%是扩散皮肤SSc.
- 普遍存在的自身抗体是:抗中心 (38.9%),抗毒素酶I (33.5%),抗RNA聚合酶III (12.4%),抗U1 RNP (12.9%).
- 最常见的器官参与:间歇性肺病 (56.0%),上部GI (42.5%). 抗TOPO I与患者的总体评估较差;抗RNAP III与医生的总体评估较差.
结论:
- 日本SSc注册表提供了有关当代患者特征的宝贵现实数据.
- 本资源有助于了解日本SSc的临床范围和结果.
- 基线数据为SSc管理的未来研究和临床实践提供信息.
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