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Updated: Jan 11, 2026

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由TOP6BL变种引起的非阻塞性亚子精的机制

Chao Wang1,2,3, Yanwei Sha4, Yayun Ji3

  • 1Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Reproduction (Cambridge, England)
|November 10, 2025
PubMed
概括

TOP6BL基因中的遗传变异与非阻塞性精子缺血症 (NOA) 相关,这是男性不孕症的原因. 这些TOP6BL变种破坏了DNA双链断裂的形成,导致介质性停止和精子生成受损.

关键词:
在TOP6BL中.DNA 双链断裂发生这种基因变异的基因变异.非阻塞性阿佐精子症.自体变质的自我变质.

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