全球纵向应变以早期检测败血性休克中的心肌功能障碍:系统性审查
Maria Luisa Garo1, Marta DI Folco2, Maria G Celestino2
1Anaesthesia and Intensive Care Research Unit, Campus Bio-Medico University, Rome, Italy - marialuisa.garo@unicampus.it.
Minerva anestesiologica
|November 10, 2025
概括
全球纵向菌株 (GLS) 检测到早期心脏功能障碍在败血性休克患者,即使在正常的射出分数. 这种敏感的标志物有助于预测死亡率和指导ICU治疗.
科学领域:
- 心脏病学 心脏病学
- 密集护理医学 密集护理医学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 败血症引起的心肌功能障碍 (SIMD) 是败血症休克的常见并发症.
- 传统的心声回声学在诊断早期SIMD时存在局限性.
- 全球纵向应变 (GLS) 通过斑点跟踪回声心脏学 (STE) 提供了一个敏感的,负载独立的标记.
研究的目的:
- 评估GLS在患有败血性休克的ICU患者的诊断和预后价值.
- 为了将GLS与传统的心声回声学参数 (如LVEF) 进行比较.
主要方法:
- 按照PRISMA指南进行系统审查.
- 在没有限制的情况下搜索了四个数据库 (PubMed,Scopus,Web of Science,Cochrane).
- 包括5项研究,包括416名患有败血症或败血性休克的成年患者.
主要成果:
- 在败血症休克患者中,GLS显著降低,即使保留了LVEF.
- 预测死亡率的GLS值为-13%至-15%,与生物标志物相关.
- 在亚临床功能障碍和康复监测方面,GLS的灵敏度高于LVEF.
结论:
- GLS是早期检测和监测心肌功能障碍在败血症休克中的有希望的工具.
- 将GLS整合到ICU实践中可能会改善风险分层和治疗.
- 需要进一步的多中心研究来标准化GLS切断值并确认临床益处.
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