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咖啡消费和多发性硬化症 (MS) 风险:系统性审查和元分析
Mohsen Rastkar1,2, Erfan Jannatalipour1, Aida Mohamadi2
1Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Neurodegenerative disease management
|November 10, 2025
概括
咖啡消费可能会降低患多发性硬化症 (MS) 的风险. 这次系统性审查和元分析发现,合并的几率比率为0.78,但异质性限制了结论.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 营养科学 营养科学
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 生活方式因素,如咖啡消费在MS风险中的作用正在调查中.
研究的目的:
- 估计与咖啡消费相关的发展MS的合并几率比率.
- 综合现有关于咖啡和MS风险研究的证据.
主要方法:
- 发表文献的系统审查和元分析.
- 在多个数据库 (PubMed,Scopus等) 进行了搜索. 和灰色文学直到2024年1月.
- 包括8项研究,包括2193例多发性硬化病例和2344例对照病例.
主要成果:
- 对8项涉及2193例多发性硬化病例和2344例对照病例的研究进行了综合分析.
- 咖啡消费与MS的风险降低有关 (OR = 0.78;95% CI:0.69-0.88).
- 观察到显著的异质性 (I2 = 92.9%,p < 0.001).
结论:
- 咖啡消费似乎与患多发性硬化症的风险降低有关.
- 包含的研究中的大量异质性限制了这一发现的强度和通用性.
- 建议进行更大规模的多中心研究来证实这些结果.
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