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Updated: Jan 11, 2026

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新型泛TEAD和亚型选择性抑制剂的表型命中识别和优化

Timo Heinrich1, Alessia Gambardella1, Daniel Schwarz1

  • 1Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.

Journal of medicinal chemistry
|November 10, 2025
PubMed
概括

研究人员发现了新型的5-azaindole和pyrrolo-pyridinone化合物,可以抑制YAP-TEAD转录. 这些抑制剂在肺癌模型中显示出抗瘤活性,并具有组合治疗的潜力.

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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