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Updated: Jan 11, 2026

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在正常血压下,与伪阿尔多斯特隆症并发的Posaconazole诱导的原发性上腺功能不足
Miho Katsumata1,2, Masaki Miura2, Masahiro Masuzawa2
1Department of Diabetes and Endocrinology, Nara Medical University, Kashihara, Japan.
Endocrinology, diabetes & metabolism case reports
|November 10, 2025
概括
波萨可纳可以导致原发性上腺功能衰竭 (PAI),而不会出现低血压和高的典型症状. 上腺轴的恢复是可能的,但调节盐和水的激素系统可能需要更长的时间才能正常化.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 主要上腺功能不全 (PAI) 经常与低血压和高胆固醇血症有关.
- 据报道,包括波萨可纳在内的醇抗真菌药物会导致PAI.
- 波萨可纳诱导的PAI缺乏典型的低血压和高胆血症的具体表现没有得到充分证实.
研究的目的:
- 报告波萨可纳诱导的PAI病例,没有低血压和高胆血症.
- 为了研究在断药后,下丘脑-垂体-上腺轴和氨酸- ангиотензин-阿尔多斯特系统的恢复.
主要方法:
- 一个74岁的男性患者的病例报告,诊断出淋巴瘤和随后的肺炎.
- 使用波萨康纳治疗肺炎.
- 诊断评估包括早晨皮质醇,上腺皮质激素 (ACTH) 水平,以及快速ACTH刺激测试.
- 在停止用波萨科纳和开始用皮质替代药物后,对临床症状,血压,水平和荷尔蒙轴的监测.
主要成果:
- 患者患有PAI,血压正常,低血压,尽管接受了波萨可纳治疗.
- 停止服用波萨康纳和开始服用皮质导致症状改善.
- 下垂体-垂体-上腺轴在停止治疗后的一个月内正常化.
- 氨酸- ангиотензин- алдостерон系统表现出持续的异常,表明正在进行的伪超氨酸.
结论:
- 波萨可纳可以诱导PAI,但可能不会出现经典的低血压和高血压.
- 虽然下丘脑-垂体-上腺轴可以相对快速恢复,但氨酸- ангиотензин-阿尔多斯特系统的恢复可能会延迟.
- 需要仔细管理低血,直到与之相关的伪高丸子症的解决.
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