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Updated: Jan 11, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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通过HER2表达和结合的丧失来实现对Trastuzumab Deruxtecan (T-DXd) 的抵抗

Wanyi Chen1, Avantika Gupta2, Nicholas Mai3

  • 1Weill Cornell Medicine, New York, NY, United States.

Cancer discovery
|November 10, 2025
PubMed
概括

转移性乳腺癌中对T-DXd的耐药性通常涉及减少HER2表达或突变. 将T-DXd与TROP2-定向抗体-药物联合体结合起来,可以通过改善药物输送来克服这种抵抗.

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