三维左心房应变与一般人群的心力衰竭和心血管死亡有关
Marat Yafasov1,2,3, Flemming Javier Olsen4,5,6, Kristoffer Grundtvig Skaarup4,5,6
1Department of Cardiology, Cardiovascular Non-Invasive Imaging Research Laboratory, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Hellerup, Denmark. marat271@gmail.com.
概括
通过3D心声学测量的左心房储压力 (LASr) 预测了一般人群未来的心力衰竭和心血管死亡. 这一发现强调了LASr作为心血管事件的有价值的预后标志物.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 通过3D心声学 (3DE) 评估左心房 (LA) 功能,使用储应变 (LASr),导管应变 (LAScd) 和收缩应变 (LASct).
- 在一般人群中,LA菌株对发作性心力衰竭 (HF) 和心血管 (CV) 死亡的预后价值仍未得到研究.
研究的目的:
- 调查3DE评估的LA菌株参数 (LASr,LAScd,LASct) 与发生高血压和心血管死亡的风险之间的关联.
- 确定LA菌株是否是一般人口队列中心血管结果的独立预测因子.
主要方法:
- 对一般人口样本进行前性纵向队列研究 (第五次哥本哈根城市心脏研究).
- 包括3DE在内的综合性胸前心声学,以量化LASr,LAScd和LASct.
- 根据ARIC-HF风险评分进行调整的考克斯比例危险回归分析.
主要成果:
- 在1954名参与者中,89人经历了HF或CV死亡的复合终点在4.8年的中位随访期间.
- 调整后的分析显示,LASr与复合结果有显著的相关性 (HR 1.28每5%的下降,p=0.004).
- 在多变量调整后,LAScd和LASct与复合结果没有显著的关联.
结论:
- 通过3DE评估的左心房储压力 (LASr) 是发生心力衰竭和心血管死亡的独立预测因子.
- 在一般人群中,LASr是心血管事件的有价值的预后标记.
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